Die Tyrosinkinase Fyn ist ein Enzym in Wirbeltieren, das die Phosphorylierung mehrerer Proteine an der Aminosäure Tyrosin katalysiert (Tyrosinkinase). Diese Reaktion ist Teil von etwa einem Dutzend Signalwege, die unentbehrlich für die Embryonalentwicklung des Gehirns und dessen spätere Funktion sind. Beim Menschen kontrolliert Fyn das Wachstum der Axone und den Calciumgehalt von Zellen. Von den drei bekannten Isoformen wird 'B' besonders im Gehirn und 'T' in T-Zellen exprimiert.[2]

Tyrosinkinase Fyn
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur 537 Aminosäuren
Kofaktor Mn2+
Isoformen B, T, P06421-3
Bezeichner
Gen-Name FYN
Externe IDs
Enzymklassifikation
EC, Kategorie 2.7.10.2Tyrosinkinase
Reaktionsart Phosphorylierung von Tyrosinresten in Proteinen
Substrat Xaa-Tyr-Yaa + ATP
Produkte Xaa-TyrP-Yaa + ADP
Vorkommen
Homologie-Familie Hovergen
Übergeordnetes Taxon Wirbeltiere[1]
Orthologe
Mensch Hausmaus
Entrez 2534 14360
Ensembl ENSG00000010810 ENSMUSG00000019843
UniProt P06241 P39688
Refseq (mRNA) NM_002037 NM_001122892
Refseq (Protein) NP_002028 NP_001116364
Genlocus Chr 6: 111.66 – 111.87 Mb Chr 10: 39.37 – 39.57 Mb
PubMed-Suche 2534 14360

Interaktionen Bearbeiten

Für FYN wurden einige Interaktionen mit anderen Proteinen nachgewiesen.

Literatur Bearbeiten

Quellen, Zitatnachweise, Zeitschriftenartikel Bearbeiten

  1. Orthologe bei OMA
  2. UniProt P06421
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